The evolution of transfusion medicine is increasingly defined by one central shift: moving care closer to the point of injury. Prehospital transfusion, once limited to military and select air medical programs, is now gaining traction across civilian trauma systems. The goal is straightforward: initiate resuscitation earlier, reduce time to blood product administration, and improve outcomes…

The renewed interest in LTOWB is rooted in trauma care. Hemostatic resuscitation strategies emphasize early, balanced replacement of red cells, plasma, and platelets. Whole blood inherently delivers this balance in a single unit.